n this study, the effects of egg intake on the prevention of Alzheimer’s disease in animal models of dementia were investigated. Purified diets with eggs were given continuously from one month prior to animal mating to three weeks after giving birth. Egg yolk was orally administered to the next generation rats from the 3rd to the 8th week after birth. Animals were divided into four groups and orally administered egg yolk daily for 30 days: CON (control group, saline), T1 (pork belly oil), T2 (egg yolk), and T3 (T1 and T2 cross-administration every week). The SREPB-1c mRNA gene expression in the liver of next generation normal animals fed diets with egg was down-regulated in T2, but the LPL mRNA gene expression in the liver, and PPARα mRNA in adipose tissue was up-regulated (p < 0.05). In terms of the animal models of dementia, T2 showed the fastest Morris water maze result, followed by CON, T1, and T3, in that order (p < 0.05). According to the result of merging neurons by the immunofluorescence image of the hippocampus in the animal models of dementia, neurogenesis by DCx, CREB, p-CREB, β-actin western blot of the hippocampus was accelerated in T2 (p < 0.05). This study revealed the new facts that egg intake could significantly help in preventing Alzheimer’s disease in the next generation of animals.