The possibility to derive immune cells from hematopoietic and non-hematopoietic progenitors was investigated. Despite the established activated proliferative activity of hematopoietic cellular progenitors, incubated in the presence of appropriate cytokine combinations, statistically significant differences were noted only in the presence of the combination IL-15/IL-18, compared with the non-treated controls, but also with the cells, incubated in the presence of other cytokines and cytokine combinations such as Il-12/IL-15 and IL-12/IL-18. The noted signs of initial myeloid and lymphoid progenitors, as well as of further phagocyte and plasmatic cell differentiation, respectively, confirmed the preserved non-malignant characteristics and immunogenic capacity in in vitro-conditions of the received sub-populations of cells, containing additionally-inserted oncogene copy. Furthermore, a capability of non-myeloid and non-lymphoid cells to produce membrane receptor glycoproteins was suggested. In analogical way was demonstrated the preserved non-malignant characteristics and adequate immune response of human embryonic trophoblasts, immortalized by virus SV40. Besides the established morphological similarities, many signs of analogy in the electrophoretic profiles were established in the protein compositions between the separate tested biological samples. Similarly to seminal plasma, synovia fluid and the extracts of the tested anatomic organs (brain and pancreas) contained proteins, produced by different types of normal cells in various phases of maturation and differentiation. Future studies are necessary.